IP6 & Inositol

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Ip-6: Health Benefits, Side Effects, Uses, Dose & Precautions

Learn more about Ip-6 health benefits, uses, side effects, effectiveness, safety, precautions, and warnings

www.rxlist.com

 

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Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic - PubMed

Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells. It was recently recognized to possess multiple biological functions. A striking anticancer effect of IP6 was demonstrated in...

pubmed.ncbi.nlm.nih.gov

 

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IP6: a novel anti-cancer agent - PubMed

Inositol hexaphosphate (InsP6 or IP6) is ubiquitous. At 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) as well as inositol (Ins) are contained in most mammalian cells, wherein they are important in regulating vital cellular functions such as signal...

pubmed.ncbi.nlm.nih.gov

 

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http://www.ip-6.net/The_Science.html

 

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Protection against cancer by dietary IP6 and inositol - PubMed

Inositol hexaphosphate (IP(6)) is a naturally occurring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain high-fiber diets, such as cereals and legumes. In addition to being found in plants, IP(6) is contained in almost all mammalian cells, although in much...

pubmed.ncbi.nlm.nih.gov

 

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Influence of pH on the Cytotoxic Activity of Inositol Hexakisphosphate (IP6) in Prostate Cancer

Objectives: In the present study, we investigated whether the pH of IP6 could influence its anti-tumoral activity in vitro. Methods: PC-3 cells were exposed to IP6 at pH 5, pH 7, and pH 12 and we evaluated the metabolic activity (WST-1 assay), cell proliferation (cell count), cell cycle...

www.frontiersin.org

 

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Inositol protects DNA from radiation

Research has shown that inositol as well as inositol hexaphosphate (IP6) helps to protect the body's genetic material from the damaging effects of ultraviolet B (UVB) and other radiation. Abulkalam M.

www.linkedin.com

 

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https://www.researchgate.net/publication/263997090_The_Effect_of_Inositol_and_Phytic_Acid_on_Skin

 

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A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine - PubMed

Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized. A key obstacle in inositol phosphate research in mammalian cells has been the lack...

pubmed.ncbi.nlm.nih.gov

Conundrum of IP6 | Open Biology

Here are comments on the recent paper on the determination of inositol hexaphosphate (IP6) in human plasma and on its efficacy.

royalsocietypublishing.org

There is no ‘Conundrum’ of InsP6

Indirect assays have claimed to quantify phytate (InsP[6] ) levels in human biofluids, but these have been based on the initial assumption that InsP[6] is there, an assumption that our more direct assays disprove. We have shown that InsP[6] does not ...

www.ncbi.nlm.nih.gov

 

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Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway

Colorectal cancer, one of the most common tumors, is mainly fatal because of the occurrence of liver metastasis. Inositol hexaphosphate (IP6) and inositol (INS) were found, both, in vitro and in vivo to play an anti-tumor effect, whereas the combination ...

www.ncbi.nlm.nih.gov

 

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Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study

Prospective, randomized, pilot clinical study was conducted to evaluate the beneficial effects of inositol hexaphosphate (IP[6] ) + Inositol in breast cancer patients treated with adjuvant therapy.Patients with invasive ductal breast cancer where polychemotherapy ...

www.ncbi.nlm.nih.gov

 

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Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate

Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathological settings. Deregulated inositol metabolism has been recorded in a number of diseases, including cancer, where inositol modulates different critical pathways...

www.hindawi.com

 

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Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats - PubMed

InsP(6) can increase blood NK cell activity in DMH-induced colon tumor in rats and inhibit tumor growth and metastasis in rats.

pubmed.ncbi.nlm.nih.gov

 

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Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression - PubMed

In recent studies, we have demonstrated that inositol hexaphosphate (InsP6) inhibits experimental colon carcinogenesis. Since natural killer (NK) cells are involved in tumor cell destruction, we investigated the effect of InsP6 on murine NK cell activity. We show that; (i) 1,2-dimethylhydrazine...

pubmed.ncbi.nlm.nih.gov

 

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Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways - PubMed

Inositol hexaphosphate (IP6) is a dietary compound commonly obtained from corn, rice, etc. Although we may consume significant amount of IP6 daily, it is unclear whether this diet will impact macrophages' fate and function. Therefore, we characterized the underlying relationship between IP6 and...

pubmed.ncbi.nlm.nih.gov

 

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Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis - PubMed

Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn's disease...

pubmed.ncbi.nlm.nih.gov

 

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Cancer Prevention by Natural Products Introduced into the Diet-Selected Cyclitols - PubMed

Cancer is now the second leading cause of death worldwide. It is estimated that every year, approximately 9.6 million people die of oncologic diseases. The most common origins of malignancy are the lungs, breasts, and colorectum. Even though in recent years, many new drugs and therapeutic...

pubmed.ncbi.nlm.nih.gov

 

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IP6 - Search Results - PubMed

IP6 - Search Results - PubMed

pubmed.ncbi.nlm.nih.gov

 

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Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancer - PubMed

Treatment of pancreatic cancer with the common dietary polyphosphorylated carbohydrate IP6 significantly decreased cellular growth and increased apoptosis. Our findings suggest that IP6 has the potential to become an effective adjunct for pancreatic cancer treatment. Further in vivo and human...

pubmed.ncbi.nlm.nih.gov

 

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New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review - PubMed

Inositol, or myo-inositol, and associated analog molecules, including myo-inositol hexakisphosphate, are known to possess beneficial biomedical properties and are now being widely studied. The impact of these compounds in improving diabetic indices is significant, especially in light of the high...

pubmed.ncbi.nlm.nih.gov

 

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Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics - PubMed

IP6 was biocidal against all tested microorganisms. At concentrations of 0.5%, 1% and 2%, IP6 required 5 min to exert a bactericidal effect on <i>E. faecalis</i>, while 5% IP6 was bactericidal after 30 s. IP6 also eradicated biofilms of the tested microorganisms. In conclusion, IP6 had notable...

pubmed.ncbi.nlm.nih.gov

 

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Molecular mechanisms for the antitumor activity of inositol hexakisphosphate (IP6) - PubMed

The results of this study show that IP6 is a strong inducer of differentiation (cytostatic effect) and a moderately strong inducer of apoptosis (cytotoxic effect). Evidence has been provided to show that the growth inhibitory effects of IP6 are mediated through the modulation of key signaling...

pubmed.ncbi.nlm.nih.gov

 

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Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells - PubMed

Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a "natural cancer fighter", being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In...

pubmed.ncbi.nlm.nih.gov

 

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Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells - PubMed

Inositol hexaphosphate (IP6), a dietary agent, has been extensively studied for its cancer chemopreventive and anti-cancer efficacy in several different animal models, but not in prostate cancer (PCA) possibly because the known PCA models are both expensive and highly time-consuming. One such...

pubmed.ncbi.nlm.nih.gov

 

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Anti-cancer activity of the cell membrane-permeable phytic acid prodrug - PubMed

Phytic acid (IP6) is an ingredient in cereals and legumes, and limited amounts of this compound are considered to enter the cell and exert anti-cancer effects. These effects have been seen by studying cells treated with around 1-5 mM IP6. However, such a large amount of IP6 chelates metals and...

pubmed.ncbi.nlm.nih.gov

 

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Inositol Pyrophosphates: Signaling Molecules with Pleiotropic Actions in Mammals - PubMed

Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of PP-IPs is mediated by IP6 kinases (IP6Ks) and PPIP5 kinases (PPIP5Ks), which transfer phosphate to inositol...

pubmed.ncbi.nlm.nih.gov

 

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Prostate cancer and inositol hexaphosphate: efficacy and mechanisms - PubMed

There are now extensive scientific data suggesting the potential role of dietary and non-dietary phytochemicals in the prevention and control of prostate cancer (PCA) growth and progression. PCA is a disease of elderly male populations with a relatively slower rate of growth and progression as...

pubmed.ncbi.nlm.nih.gov

 

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Anti-angiogenic activity of inositol hexaphosphate (IP6) - PubMed

A significant anticancer activity of the naturally occurring carbohydrate inositol hexaphosphate (IP(6)) has been reported against numerous cancer models. Since tumors require angiogenesis for growth and metastasis, we hypothesize that IP(6) reduces tumor growth by inhibiting angiogenesis...

pubmed.ncbi.nlm.nih.gov

 

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In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor - PubMed

IP6 suppresses hormone-refractory PCA growth accompanied by inhibition of tumor cell proliferation and angiogenesis and increased apoptosis. IP6-caused increase in IGFBP-3 and decrease in VEGF might have a role in PCA growth control.

pubmed.ncbi.nlm.nih.gov

 

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Phytase in non-ruminant animal nutrition: a critical review on phytase activities in the gastrointestinal tract and influencing factors - PubMed

This review focuses on phytase functionality in the digestive tract of farmed non-ruminant animals and the factors influencing in vivo phytase enzyme activity. In pigs, feed phytase is mainly active in the stomach and upper part of the small intestine, and added phytase activity is not recovered...

pubmed.ncbi.nlm.nih.gov