Puzzle pieces.... Parp1, DNA repair, ect

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Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50

Genome instability is the fundamental hallmark of malignant tumors. Tumor suppressors often play a role in maintaining genome stability. Our previous genetic screen identified inositol polyphosphate 4-phosphatase type B (INPP4B), primarily hydrolyzing ...

www.ncbi.nlm.nih.gov

 

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PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response. PARP1 possesses Poly (ADP-ribose) activity and when activated by DNA damage, adds branched PAR chains to facilitate...

www.frontiersin.org

 

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Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases

PARP-1 (poly(ADP-ribose)-polymerase 1), mainly known for its protective role in DNA repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic inflammation may both predispose to cancer development. On the other hand, inhibition of DNA repair and inflammatory...

www.mdpi.com

 

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PARP inhibitor resistance: the underlying mechanisms and clinical implications - Molecular Cancer

Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) polymerase (PARP) have been approved for ovarian cancer and breast cancer indications...

molecular-cancer.biomedcentral.com

 

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Parp1 promotes sleep, which enhances DNA repair in neurons

The characteristics of the sleep drivers and the mechanisms through which sleep relieves the cellular homeostatic pressure are unclear. In flies, zebr…

www.sciencedirect.com

 

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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling - Nature Reviews Molecular Cell Biology

Recent insights into the roles of poly(ADP-ribose) polymerase 1 (PARP1) in mediating various DNA repair pathways, stabilizing DNA replication and modulating chromatin structure are being exploited clinically for the treatment of DNA repair-deficient cancers.

www.nature.com

 

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The role of SIRT6 in tumors

www.ncbi.nlm.nih.gov

 

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DEFINE_ME

www.exphem.org

 

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Is sleep linked to neuronal DNA damage?

New research in zebrafish finds that a protein called PARP1 detects neuronal DNA injury, induces sleep, and DNA repair during sleep.

www.medicalnewstoday.com

 

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PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.

elifesciences.org

 

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SIRT6 promotes DNA repair under stress by activating PARP1

SIRT6 is a mammalian homolog of the yeast Sir2 deacetylase that promotes longevity in yeast and invertebrates. Mice deficient for SIRT6 exhibit premature aging and genome instability. Here we show that in mammalian cells subjected to oxidative stress ...

www.ncbi.nlm.nih.gov

 

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Dietary Flavones and Flavonoles Are Inhibitors of Poly(ADP-ribose)polymerase-1 in Pulmonary Epithelial Cells

Abstract. The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1), which was initially known to be highly activated by oxidative stress-induced DNA strand bre

academic.oup.com

 

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Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells

Resistance to current cancer treatments is an important problem that arises through various mechanisms, but one that stands out involves an overexpression of several factors associated with DNA repair. To counteract this type of resistance, different drugs have been developed to affect one or...

www.frontiersin.org

 

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The HSF1–PARP13–PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis

Poly(ADP-ribose) polymerase 1 (PARP1) is involved in DNA repair, chromatin structure, and transcription. However, the mechanisms that regulate PARP1 distribution on DNA are poorly understood. Here, we show that heat shock transcription factor 1 (HSF1) ...

www.ncbi.nlm.nih.gov

 

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PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced by changes in cell homeostasis promotes development of chronic pathological ...

www.ncbi.nlm.nih.gov